Best for: All skin types concerned with expression lines, contraction wrinkles, uneven texture, visible pores, dullness and loss of radiance.

What is SkinCeuticals P-TIOX?

SkinCeuticals P-TIOX is an advanced peptide anti-wrinkle serum designed to visibly reduce the appearance of nine types of contraction lines while improving skin texture, brightness and radiance.

The wrinkle-modulating formula combines an Advanced Peptide Complex with 2% hexapeptide and 2% dipeptide, alongside 5% PHA, 5% niacinamide and 1% Laminaria extract.

This combination targets visible contraction lines while helping smooth skin texture, make pores appear smaller and enhance skin's glow for a glass-skin radiance effect. The formula also provides intense hydration lasting 24 hours and helps strengthen the skin's barrier within one hour.

Who is it best for?

SkinCeuticals recommends P-TIOX for:

• dry skin

• normal skin

• oily skin

• combination skin

• sensitive skin

• ageing skin

• fine lines and wrinkles

• forehead wrinkles

• lines between the eyebrows

• crow's feet

• under-eye wrinkles

• nasolabial folds

• marionette lines

• cheek folds

• visible pores

• uneven skin texture

• dull-looking skin

• skin lacking radiance

• anyone looking for an anti-wrinkle peptide serum

P-TIOX has also been tested and is suitable for use on all skin tones.

What problem does it solve?

Repeated facial expressions and muscle contractions can contribute to the development of visible expression wrinkles or contraction lines, particularly around the forehead, eyes and between the eyebrows.

P-TIOX combines an Advanced Peptide Complex with PHA, niacinamide and Laminaria extract to target the visible appearance of these lines while simultaneously improving skin texture, brightness, hydration and radiance.

In a 12-week clinical study involving 82 subjects, P-TIOX was proven to visibly reduce nine types of contraction lines.

Contraction lines + wrinkles + uneven texture + dullness → Advanced Peptide Complex + 5% PHA + 5% niacinamide + 1% Laminaria extract → visibly smoother lines and texture + enhanced radiance.

Benefits:

• Proven to visibly reduce nine types of contraction lines*

• Helps reduce the visible appearance of wrinkles

• Helps improve forehead wrinkles

• Helps improve glabellar wrinkles

• Helps improve crow's feet

• Helps improve nasolabial folds

• Helps improve cheek fold wrinkles

• Helps improve marionette wrinkles

• Helps improve under-eye wrinkles

• Helps improve inter-ocular wrinkles

• Helps improve global fine lines

• Visibly improves skin texture

• Helps skin appear smoother

• Helps pores appear smaller

• Enhances skin brightness

• Enhances skin radiance and glow

• Helps reveal glass-skin radiance

• Provides intense hydration lasting 24 hours

• Helps strengthen the skin barrier within one hour

• Contains an Advanced Peptide Complex

• Contains 5% PHA

• Contains 5% niacinamide

• Contains 1% Laminaria extract

• Suitable for all skin tones

• Suitable for sensitive skin

• Fragrance-free

• Suitable for use morning and evening

• Can be used with retinol

*12-week clinical study, 82 subjects.

The 9 Types of Contraction Lines

After 12 weeks, SkinCeuticals reports visible reduction in:

1. Nasolabial folds

2. Forehead wrinkles

3. Glabellar wrinkles

4. Crow's feet wrinkles

5. Cheek fold wrinkles

6. Marionette wrinkles

7. Under-eye wrinkles

8. Inter-ocular wrinkles

9. Global fine lines

*12-week clinical study, 82 subjects.

Key Ingredients & Technology:

Advanced Peptide Complex – 2% Hexapeptide + 2% Dipeptide: Peptides designed to help improve the appearance of key contraction lines.

5% PHA: A gentle exfoliating ingredient that SkinCeuticals states helps improve skin texture, promote cell turnover and enhance overall skin radiance.

5% Niacinamide: Also known as vitamin B3. SkinCeuticals states that topical niacinamide helps strengthen the skin's moisture barrier and reduce the appearance of discolouration and blotchiness.

1% Laminaria Extract: A natural ingredient derived from brown seaweed that SkinCeuticals identifies for its hydrating and skin-soothing properties.

How to Use:

• Use P-TIOX twice daily, morning and evening.

• Apply 5–6 drops of serum to the palm of your hand.

• Dab the serum onto the forehead, cheeks and chin.

• Blend the product into the skin until absorbed.

• Apply to dry skin.

Morning: Apply P-TIOX after your SkinCeuticals vitamin C antioxidant serum and before your SkinCeuticals sunscreen.

Evening: P-TIOX can also be incorporated into your evening skincare routine and can be used with retinol.

Why Choose It?

Skin types: Dry + Normal + Oily + Combination + Sensitive
Skin concerns: Ageing + Fine Lines + Wrinkles + Contraction Lines + Uneven Texture + Visible Pores + Dullness
Best for: Expression lines and visible signs of ageing
Product type: Anti-wrinkle peptide facial serum
Key benefits: Wrinkle Reduction + Smoother Texture + Radiance + Brightness + Hydration + Skin Barrier Support
Peptide complex: 2% Hexapeptide + 2% Dipeptide
PHA: 5%
Niacinamide: 5%
Laminaria extract: 1%
Clinically tested: Yes
Contraction lines targeted: 9 types*
Hydration: Up to 24 hours
Helps strengthen skin barrier: Within 1 hour
Helps pores appear smaller: Yes
Enhances skin radiance: Yes
Suitable for all skin tones: Yes
Suitable for sensitive skin: Yes
Fragrance-free: Yes
Can be used with retinol: Yes
Use: Morning + Evening
Frequency: Twice daily
Amount: 5–6 drops
Application areas: Face
Size: 30ml
Routine step: Correct / Anti-ageing serum
Brand: SkinCeuticals

*12-week clinical study, 82 subjects.

Millies Expert Advice:

If expression lines are becoming more noticeable around the forehead, eyes, between the brows or lower face, P-TIOX is specifically designed to target these visible contraction lines rather than focusing only on general skin ageing.

The formula combines 2% hexapeptide + 2% dipeptide with 5% PHA, 5% niacinamide and 1% Laminaria extract, so you're also addressing texture, visible pores, radiance and hydration alongside wrinkles.

For your morning routine, apply your SkinCeuticals vitamin C antioxidant serum first, followed by 5–6 drops of P-TIOX, then complete your routine with sunscreen.

Is SkinCeuticals P-TIOX right for me?

Choose this serum if: contraction lines, expression wrinkles, uneven skin texture, visible pores or loss of radiance are among your main skincare concerns.

It may be particularly suitable if: you want a peptide-based anti-wrinkle serum that addresses several visible signs of ageing in one formula while also providing hydration and helping improve skin texture and radiance.

SkinCeuticals recommends P-TIOX for dry, normal, oily, combination and sensitive skin, and it has been tested and found suitable for all skin tones.

Important distinction – P-TIOX and anti-wrinkle injections

P-TIOX is a topical cosmetic skincare serum. It is not an injectable treatment and should never be injected.

SkinCeuticals states that P-TIOX is suitable for use in between anti-wrinkle injections. If you are considering or have undergone an aesthetic treatment, always consult a medical professional and only apply P-TIOX to healed skin.

Frequently Asked Questions

What is SkinCeuticals P-TIOX?
SkinCeuticals P-TIOX is an advanced peptide anti-wrinkle facial serum designed to visibly reduce nine types of contraction lines while improving skin texture, radiance and brightness.

What does SkinCeuticals P-TIOX do?
It helps reduce the visible appearance of contraction lines and wrinkles while helping smooth skin texture, make pores appear smaller and enhance skin radiance.

What are contraction lines?
SkinCeuticals describes contraction or expression wrinkles as lines caused by repeated facial muscle contraction. They commonly appear around the eyes, forehead and between the eyebrows.

Which wrinkles does SkinCeuticals P-TIOX target?
SkinCeuticals reports visible improvement in nine types: nasolabial folds, forehead wrinkles, glabellar wrinkles, crow's feet, cheek fold wrinkles, marionette wrinkles, under-eye wrinkles, inter-ocular wrinkles and global fine lines.

How long does SkinCeuticals P-TIOX take to work?
SkinCeuticals' visible wrinkle results are based on a 12-week clinical study involving 82 subjects. The brand separately states that P-TIOX provides 24-hour hydration and strengthens the skin barrier within one hour.

What peptides are in SkinCeuticals P-TIOX?
P-TIOX contains an Advanced Peptide Complex consisting of 2% hexapeptide and 2% dipeptide.

How much PHA is in SkinCeuticals P-TIOX?
P-TIOX contains 5% PHA.

What does PHA do in SkinCeuticals P-TIOX?
SkinCeuticals describes its 5% PHA as a gentle exfoliating ingredient that helps improve skin texture, promote cell turnover and enhance overall skin radiance.

Does SkinCeuticals P-TIOX contain niacinamide?
Yes. P-TIOX contains 5% niacinamide.

What does niacinamide do in SkinCeuticals P-TIOX?
SkinCeuticals states that topical niacinamide helps strengthen the skin's moisture barrier and reduce the appearance of discolouration and blotchiness.

What is Laminaria extract in SkinCeuticals P-TIOX?
P-TIOX contains 1% Laminaria extract, derived from brown seaweed. SkinCeuticals identifies it for its hydrating and skin-soothing properties.

Does SkinCeuticals P-TIOX help with skin texture?
Yes. SkinCeuticals states that skin texture is visibly smoother with P-TIOX.

Does SkinCeuticals P-TIOX help with visible pores?
Yes. SkinCeuticals states that pores appear smaller while skin texture and glow are enhanced.

Does SkinCeuticals P-TIOX hydrate the skin?
Yes. SkinCeuticals states that P-TIOX provides intense hydration lasting 24 hours.

Does SkinCeuticals P-TIOX support the skin barrier?
Yes. SkinCeuticals states that P-TIOX strengthens the skin's barrier within one hour.

Is SkinCeuticals P-TIOX suitable for sensitive skin?
Yes. Sensitive skin is included among the skin types recommended by SkinCeuticals.

Is SkinCeuticals P-TIOX suitable for all skin tones?
Yes. SkinCeuticals states that P-TIOX has been tested and is suitable for all skin tones.

Is SkinCeuticals P-TIOX fragrance-free?
Yes. SkinCeuticals identifies P-TIOX as fragrance-free.

How often should I use SkinCeuticals P-TIOX?
Use P-TIOX twice daily, morning and evening.

How much SkinCeuticals P-TIOX should I use?
SkinCeuticals recommends 5–6 drops per application.

How do I apply SkinCeuticals P-TIOX?
Apply 5–6 drops to the palm of your hand, dab onto the forehead, cheeks and chin, then blend the serum into dry skin.

Can I use SkinCeuticals P-TIOX with vitamin C?
Yes. In the morning, SkinCeuticals recommends applying P-TIOX after your SkinCeuticals vitamin C antioxidant serum.

Can I use SkinCeuticals P-TIOX with retinol?
Yes. SkinCeuticals confirms that P-TIOX can be used with retinol.

Do I use SkinCeuticals P-TIOX before or after sunscreen?
Apply P-TIOX before sunscreen. In the morning, SkinCeuticals recommends vitamin C antioxidant serum first, followed by P-TIOX and then sunscreen.

Can SkinCeuticals P-TIOX be used between anti-wrinkle injections?
SkinCeuticals states that P-TIOX is suitable for use in between anti-wrinkle injections. It is a cosmetic topical skincare product, should never be injected and should only be applied to healed skin. Always consult a medical professional when considering aesthetic treatments.

What size is SkinCeuticals P-TIOX?
SkinCeuticals P-TIOX contains 30ml.

Ingredients:

AQUA / WATER / EAU, NIACINAMIDE, GLUCONOLACTONE, BUTYLENE GLYCOL, PEG/PPG/POLYBUTYLENE GLYCOL-8/5/3 GLYCERIN, ALCOHOL DENAT., PENTYLENE GLYCOL, METHYL GLUCETH-20, GLYCERIN, POTASSIUM HYDROXIDE, HYDROXYETHYLCELLULOSE, SALICYLIC ACID, CHLORPHENESIN, PHYTIC ACID, ADENOSINE, SODIUM BENZOATE, LAMINARIA DIGITATA EXTRACT, DIPEPTIDE DIAMINOBUTYROYL BENZYLAMIDE DIACETATE, ACETYL HEXAPEPTIDE-8.

Refer to the product packaging for the complete and most up-to-date ingredient list.